Risk Factors for Poor Survival, Recurrence in UTUC Identified
Advanced or high-grade tumors in patients with upper tract urothelial carcinoma (UTUC) are among the risk factors associated with poor prognosis and postoperative bladder cancer (BC) recurrence,...
View ArticleEarlier Pembrolizumab Use May Be Beneficial in mUC
The following article features coverage from the American Society of Clinical Oncology (ASCO) 2018 meeting. Earlier pembrolizumab treatment using a “switch maintenance” approach may delay disease...
View ArticleComplete Response to Atezolizumab in UC Appears Durable
The following article features coverage from the American Society of Clinical Oncology (ASCO) 2018 meeting. Complete response (CR) to treatment with the checkpoint inhibitor atezolizumab in patients...
View ArticleFirst-Line Pembrolizumab for Cisplatin-Ineligible UC Has Durable Benefits
The following article features coverage from the American Society of Clinical Oncology (ASCO) 2018 meeting. Updated findings from a clinical trial show that first-line pembrolizumab therapy for...
View ArticleEnfortumab Vedotin Yields High Response Rate in Advanced Urothelial Cancer
Treatment with enfortumab vedotin, an antibody-drug conjugate, elicited responses in 44% of patients with locally advanced or metastatic urothelial cancer who had failed other treatments, according to...
View ArticleAdverse Events Associated With Outcomes in PD-1/PD-L1–Treated Urothelial...
Development of an immune-mediated adverse event (imAE) associated with treatment with a PD-1/PD-L1 inhibitor was associated with improved clinical outcomes among patients with urothelial carcinoma,...
View ArticleUTUC-Related Mortality Greater in Asians Than Whites
Asians with upper tract urothelial carcinoma (UTUC) are more likely than their white counterparts to present with metastatic disease and to die from it, Dixon T.S. Woon, MBBS, of the University of...
View ArticleRenal Ultrasound Appropriate for Initial Upper Tract Evaluation
Renal ultrasound is an appropriate modality for upper tract imaging in the initial evaluation of patients with asymptomatic microscopic hematuria (AMH), according to a new study. In a study of 2138...
View ArticleUTUC With Isolated Lymph Node Involvement Predicts Poor Survival
Isolated lymph node involvement in patients with upper tract urothelial carcinoma (UTUC) is associated with poor long-term survival following surgical resection, according to investigators. Older age,...
View ArticleVariant Histology Worsens UTUC Outcomes, Study Finds
Upper tract urothelial carcinoma (UTUC) with variant histology is associated with worse outcomes among patients treated with radical nephroureterectomy (RNU), according to a systemic review and...
View ArticlePreoperative Pyuria Predicts Bladder Recurrence After UTUC Surgery
Preoperative pyuria, ureteral tumor site, and positive surgical margins are risk factors for intravesical recurrence (IVR) in patients without a history of bladder cancer who undergo radical...
View ArticleAdjuvant Chemotherapy Improves Outcomes in Locally Advanced UTUC
While neoadjuvant chemotherapy appears beneficial in high-risk upper tract urothelial carcinoma (UTUC), some patients do not receive it due to their preference or limited insurance coverage. For these...
View ArticleNeoadjuvant Chemo Leads to Downstaging in Some UTUC Cases
Neoadjuvant chemotherapy (NAC) can lead to tumor downstaging and better survival for some patients with nonmetastatic upper tract urothelial carcinoma (UTUC), according to new study findings published...
View ArticleSegmental Ureterectomy an Option in Some UTUC Cases
While radical nephroureterectomy (RNU) is the gold standard for patients with upper tract urothelial carcinoma (UTUC), segmental ureterectomy (SU) may be an option for some patients, according to new...
View ArticleUpper Tract Urothelial Cancer Treatment Granted Priority Review
The FDA has granted priority review to a New Drug Application (NDA) for a mitomycin gel formulation to treat low-grade upper tract urothelial cancer (UTUC). If approved, the product would be the first...
View ArticlePTRF Biomarker May Predict UTUC Progression, Survival
Elevated polymerase I and transcript release factor (PTRF) may portend aggressive disease and poor survival following radical nephroureterectomy for upper tract urothelial carcinoma (UTUC), according...
View ArticleLymph Node Dissection Ups Survival in Higher-Stage UTUC
Patients with nonmetastatic stage 3 to 4 upper tract urothelial carcinoma (UTUC) may benefit from lymph node dissection, new study findings suggest. Whether stage 1 to 2 patients also benefit from the...
View ArticleIMRT a Possible Option for Upper Tract Urothelial Carcinoma
Intensity-modulated radiation therapy (IMRT) is a possible primary option for patients with localized upper tract urothelial carcinoma (UTUC) unsuitable for surgery, according to Hao-Wei Chen MD, of...
View ArticleNeoadjuvant Chemotherapy Appears Effective for High-Risk UTUC
Pathologic downstaging following neoadjuvant chemotherapy (NAC) predicts better survival in high-risk upper tract urothelial carcinoma (UTUC) patients, researchers reported in The Journal of Urology....
View ArticleDistal Ureteral Management Methods Compared in UTUC
Intrasvesical incision of the bladder cuff (IVBC) may provide better oncologic outcomes than non-intrasvesical techniques among patients undergoing radical nephroureterectomy for upper urinary tract...
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